NHC-catalyzed cleavage of vicinal diketones and triketones followed by insertion of enones and ynones

• Ken Takaki,
• Makoto Hino,
• Akira Ohno,
• Kimihiro Komeyama,
• Hiroto Yoshida and
• Hiroshi Fukuoka

Beilstein J. Org. Chem. 2017, 13, 1816–1822, doi:10.3762/bjoc.13.176

• ; N-heterocyclic carbene; ring enlargement; Stetter reaction; vicinal polyketone; Introduction N-Heterocyclic carbenes (NHCs) have been indispensable catalysts for organic synthesis, particularly for umpolung of various functional groups [1][2][3][4][5][6][7][8][9]. In the Stetter reaction, NHCs